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Diabetes Breakthrough: New Treatment Eliminates Insulin for 86% of Patients

https://scitechdaily.com/diabetes-breakthrough-new-treatment-eliminates-insulin-for-86-of-patients/
I wouldn't ignore the effect that having surgery and then two weeks of a strictly controlled food intake has. That might account for a large proportion of the success rate. I heard about a study that found that the fasting required for bariatric surgery actually provides a large proportion of the benefit of the procedure.

If you catch type 2 diabetes before it gets so bad that it has killed off the beta cells, then your best treatment is to fast for a while. After a couple of days, you should notice a massive improvement in glucose control. A week of fasting a couple of times a year might be all it takes to give you a complete cure. YMMV, but in my opinion (and that of a whole load of people who know what they're talking about) it's better than filling yourself with drugs.

After the beta cells have been killed off by overwork, yeah, you need insulin. But you can still reduce the amount you need by losing weight.

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I’m unsurprised that a large component of the treatment is effectively just “lose weight”. For many years I’ve heard accounts of significant weight loss reversing type 2 diabetes.
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Note: This is about diabetes type 2, not type 1. Might be worth to editorialize the heading in this case.
Something that works for 95% of people with diabetes then. Fantastic!
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eh, I had a brief glimmer of hope
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Paper: https://pubmed.ncbi.nlm.nih.gov/38692517/

> Recellularization via electroporation therapy (ReCET) is a novel endoscopic procedure that uses electroporation to induce cellular apoptosis and subsequent reepithelization.

... plus GLP-1.

GLP-1s baseline eliminate insulin for about ~40% of people. This boosts that number to 86%.

Note that Tirzepatide also reduces the chance of developing type 2 in the first place by 94%, and I suspect that newer generation receptor agonists will see higher insulin discontinuation rates in general.

Very cool stuff all around. Might finally be able to put this whole obesity-and-diabetes thing to bed.

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I didn’t seem to get this from the article but this this involve taking semaglutide for the rest of your life or the diabetes returns?
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How long does this cure last until the unhealthy diet & lifestyle that originally caused the insulin resistance bring it back again?

It's frustrating, as Type 2 diabetes is 100% manageable through diet. You don't even have to exercise, just eat healthy. Today, with the use of continuous glucose monitors, you have all the data you need to make informed diet decisions - you know exactly what "eat healthy" means for your body.

Not sarcasm: I'm sure it would be frustrating to see so much scientific and commercial effort going into treating TIID pharmacologically when you believe the solution is trivial. But you could also consider all of these developments as evidence that the prescription of "just eat healthy" isn't broadly useful.
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Considering the article mentions ReCET and semaglutide, presumably most people in the study weren't resuming the unhealthy diet.

Semaglutide is ozempic. By itself it can be enough to help people get their A1C down through healthier diets.

For me to find the study especially interesting, I'd have to see a comparison between ReCET + semaglutide vs just semaglutide. And upon re-reading I see that's their plan.

> “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

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