The suckers who have their retirement savings in some kind of index fund because all the experts have been saying, "Buy index ETFs and forget about it" for decades are gonna get fleeced, and the wealthiest get wealthier.
But, that philosophy came about in an era when there were protections for small investors that prevented the richest man on earth from dipping into your retirement fund to make himself even richer. I don't know how to be a smart investor when the game is so thoroughly rigged for a handful of billionaires.
I don't really have advice. If I were directly holding an index that tracks the Nasdaq 100, I would get out of it, and take the tax hit. But, I suspect the impact and risk will cascade outward. Nvidia has exploded in price based on actual revenue (though I suspect it will be temporary, and have to come back to earth in time). SpaceX is entirely fantasy land. It doesn't have revenue to justify anything like the price they're launching the IPO, and when indexes are forced to buy it, everyone holding those indexes provides exit liquidity for the same scammers who've been hyping it.