Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
In this case some public reads "smoking a joint daily equals invulnerable to Alzheimer, science says so".
If you make a product you can make a study that shows it has some kind of benefit in some specific way, even if it probably causes more harm in other ways that are less obvious, and then you can sell it. Media will spread around your study especially if it shows something that will be a bit click-baity, and any study or discussion of the possible downsides will get far less attention.
This is also why basically every edible plant has some article saying it's a "super food" etc etc.
What all that, how can you defend opiates? Opinion of society is irrelevant here, they are absolute scourge if used enough, and nobody is immune.
i do argue that in the correct harness, opiates could be distributed to minimize unnecessary suffering at least somewhat - not 24/7, because literally any drug will result in tolerance (and debilitating physical side effects, something opiates lack) at that point. our current system is unsatisfactory - people are not taught how to take drugs correctly, and people exist in a system that naturally causes dopamine seeking reward systems to malfunction. while some are born psychologically weak, inherently leading to addiction susceptibility, society is expressly designed to produce such weakness in order to maintain the status quo. of course such an environment is not positively conducive to the dopamine flooding effects of opiates. i dont blame opiates for the system in which they exist.
regarding personality cracks, i still refer to rat park for the most part, saving brain resets such as ibogaine for extreme cases - our addiction inducing society (as a whole, not merely the opinions wherein) does not imply impossibility of rewiring addictions. regardless, some people think cracks are beautiful (ref. kintsugi).
do you argue that everyone should be instead placed on nsaids that destroy the stomach and liver, killing them earlier and objectively adding pain prior? is the current trajectory (that is, entirely depriving the suffering of effective relief, regardless as to their age bracket) for the best?
NSAIDs are known to kill your stomach, your kidney, your liver, and your heart, whereas opiates do not. And they are ineffective for a lot of people's chronic pain, on top of that.
Here is a site you can use too see how most pharmaco therapy is lacking.
https://pain-calculator.com/calculators/osteoarthritis-pain/
Very few painkillers that are not blood thinners. Paracetamol and canabinoids are a couple of rare exceptions.
My uncle broke his hip in his old age. He died shortly after because of the bleeding induced by painkillers.
Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?
Similarly, there were other drugs that lowered cholesterol that didn’t show a significant reduction in coronary events. As we later learned, it’s not nearly as simple as “cholesterol bad.”
https://pubmed.ncbi.nlm.nih.gov/41160460/#:~:text=ResultsAt%...
https://news.harvard.edu/gazette/story/2010/03/alzheimers-as...
https://www.nebraskamed.com/health/conditions-and-services/n...
But somehow I doubt it will be found to be that effective.
But fortunately there's a much better solution for those of us who get anxiety from weed, it's called "don't smoke weed".
Now that it's legal and everywhere, I just get super fun panic attacks. I'm worthless, I'm failing as a parent, everybody hates me, you know, the normal anxiety attacks. Even Charlotte's Web that's SUPER low THC gives me panic attacks.
It's like my body hates it when I'm happy? I would give anything to be able to fix this problem.
Saw someone literally suggesting keeping a CBD vape pen just in case of a panic attack. Or a friend using it for heart palpitations.
Wasn't the amount of THC concentration in resin seen as the indicator of potency? Then that amount was hacked through selective breeding, unbeknownst that not following with a complementary increase in amount of CBD will create an anxiety causing superdrug.
I experienced it once - on a party in a country where CBD strains are legal to buy by anyone, as long as they contain ~0%THC. And high quality high THC strains can be bought at a pharmacy with a prescription.
A friend rolled a 50%/50% joint, approx 0.5g total, and we proceeded to smoke it whole, just the two of us. I was surprised you could get that high without a shadow of a paranoia.
I never particularly cared for cannabis in general in the past–it didn’t give me panic attacks, but even a little bit made me feel kind of on edge. The 1:1 stuff is dramatically more pleasant.
I feel like that strain is for EXPERTS. You can always mold it to the vibe you are aiming to reach in that present (ofc in the appropriate environments).
Do you feel like the anxiety just the cascaded result of ... "poor planning" over an extended, day-over-day staggering, sleep-deprived, period of time? I consider my self naturally the poorest of poor planners. My brain is just RAM with zero cache that i always imagine that I have. I've had weeks wiz by if I do not get on top of a fun, MJ propagandized base routine / schedule in place.
Apologies! Worse case, this could just be a swing and a miss. Empathies attempted.
A couple years ago (around 40) I started taking a low dose antidepressant for unrelated reasons and noticed that the weed induced anxiety mostly disappeared. My guess is that for some people there’s a serotonin/anxiety component that THC can amplify, but that’s just speculation on my part.
Not suggesting antidepressants as a solution by themselves. They come with their own tradeoffs and I wouldn’t take them just for that. But it has been a pleasant side effect I didn’t expect.
1. I've eaten like crap. Things too heavy I'm grease, processed food, and red meats. When I'm rating cleaner, I don't feel as panicky
2. If I feel the panic coming on, I HAVE to do some sort of aerobic exercise in that first 15 minute "induction" phase of smoking. Otherwise I'll carry the panic along through the entire session.
FWIW, YMMV
5km goes by fast! And orange juice tastes great after.
Full spectrum hemp (~0%) definitely feels like the answer, here!
And also, apparently, the registered trademark?
> The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
Cannabis really needs a lot more study.
No, it has not improved my memory. Though, I am not really certain anything does. At least, not permanently. Though, I will say the effects on memory are rather complex. Some diminished abilities in some domains, but oddly some enhancements in a select few domains.
I am 'neurodivergent' apparently, so my experiences might not be worth much.