why go the hassle of taking the mainboard out, assuming you are using it as a server kindof config
You can put it in a custom case. Releasing the space constraints enforced by a laptop design means you can easily have a better cooling arrangement so experience less thermal throttling if you ask it to perform longer compute-heavy tasks.
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Well, this is about replacing a Pi, so I guess people want a raw board. Indeed, if you just want to run a pi-hole, take any old laptop and just wedge it someplace...