Hacker News new | past | comments | ask | show | jobs | submit

Found: A protein that drives ageing without unleashing inflammation

https://www.nature.com/articles/d41586-026-03638-3
Paper: https://www.cell.com/immunity/fulltext/S1074-7613(26)00440-1

Granzyme K is the protein.

loading story #50490065
From the abstract of the paper, significantly more nuance.

> Despite persistent immune aging phenotypes, GzmK deficiency markedly attenuated organ aging, effectively uncoupling immune and tissue aging... These findings identify GzmK as a tissue-specific driver of organismal aging but not immune aging or systemic inflammaging.

Thank God! Finally, mice that don't age!
loading story #50489952
loading story #50490098
In mice.
loading story #50489488