> That's actually extremely common in scientific (GUI) software. And in any professional setting I guess.

I don't think that qualifies. There's an important distinction to be made between an aesthetic preference versus a professional not appreciating a tool being mucked with. Anything that interferes with my workflow without immediately providing substantial benefit is something that's actively harmful. In fact even if it does hypothetically provide huge benefits I still might not want to deal with it right this second.