I think a specific song becoming irreversibly memeified is different from a person lacking the ability to engage unironically. I don't know if you're from my generation, but if you are, I imagine what they are experiencing is similar to how we would feel if we watched an old movie with Never Gonna Give You Up played completely straight at a key emotional moment. (But worse, because The Sound of Silence is a very delicate and emotional song, whereas Never Gonna Give You Up is inherently a bit cheesy and fun, so the contrast between the original intent and our experience wouldn't be so extreme.)