If this level of pedantry can be considered acceptable, how on earth do these folks justify/cope with terminology used in "empowerment" initiatives who often use very non-inclusive wording more so than "guys".
If another cis man was suddenly uncomfortable with "they", I'd attribute that to some fragile sense of masculinity or a weird anti-woke crusade, as was the case with most such cases in my life, and find it personally annoying.
I don't want to deliberately make other people uncomfortable with my language, but it does feel exhausting to second-guess yourself, having to double-check if any innocuous phrase might be misinterpreted as an underhanded aggression, preempting a correction we know will be awkward for both sides.
I think we'd do better to consider context more than the specific language...
I've also worked with a woman who was extremely displeased to be greeted with "you guys". I found her absolutely insufferable.
The reason it feels bad to people who use "you guys" in a gender neutral way is what it says about the offended person. The offended person has a pet peeve, and if you don't accommodate it, it will be a problem. That's pretty much the definition of an insufferable person.
A person who is well-regulated wouldn't make a stink over something so trivial. Which then tells you that the person is going to make a similar stink over other trivial things. Ad infinitum.