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If your minimum run is 1000 of a size, and you can only really sell 500 because it's an uncommon size, and you would prefer to sell at full price or not at all, seems like making that size no longer fits your plans.
Wouldn't it be cheaper to only produce 500 items, instead of producing 1k, and throwing half of it away?
Many years ago I worked in the printing industry. F.ex. a client wants 100 products of something (e.g. posters or flyers), usually it was more cost effective to produce a 1000 (or more) and then throw away 900 the client didn't need. Obviously a huge waste of material.
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1k in this example would be the minimum needed to make it worth the static cost of setting up and tearing down the production run.
> prefer to sell at full price or not at all

That really only applies to luxury designer brands where selling at a discount can dilute the brand prestige, is Gucci, Versace, etc. really destroying unsold inventory at large volumes vs. standard retailers?

Yes. The law was motivated by reports of luxury retailers destroying their entire stock every year. Usual stores just discount stuff until it sells.
But clothes aren't perishable, so why would you only be able to sell 500, rather than it just taking twice as long to sell all 1000?
Fashionable clothes are perishable. "Nobody" wants to buy clothes from last season or last year.

Storing the clothes until they come back in fashion is expensive... and some materials really won't be useful after sitting for 10 years anyway. (Elastic bands really are perishable)

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Because it won't take twice as long, but 10x as long. There's typically a large rush on a new design, followed by a slow tick in sales. Meanwhile you have to pay to warehouse it, pay tax on the inventory, etc.