As someone who works in bioinformatics, and, as such, does a great deal of machine learning, this makes Fable unusable for me as well.
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For sure Anthropic should be developing a model without these guardrails for your use case? Kinda like Mythos is only available to certain organizations.
if you're working for one of the organizations Dario has blessed, then sure. you're SOL if you're not one of the top-3 whatevers. maybe they'll let MIT, Harvard and Stanford use Mythos for biology. good luck to everyone else!