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I've tried to use software like this and it looks awesome but it wasn't ultimately the solve for me when it comes to ergonomics.

I used a logitech mx mouse with the palm shape or whatever it's called and I realized that it stopped me from putting more of my hand on the desk, pin pointing the pressure of my hand onto the mouse instead of the desk. What helped dramatically was getting a smaller mouse without that thumb/palm shape (the logitech M720 Triathlon), that distributed more of the pressure onto my desk and I haven't had an issue since.

I hope that helps for anyone having similar ergonomic issues!

That's interesting! I have been using MX for years now (on my third one in 10 years I believe) and there's nothing else that I like. Could you explain what was the issue with the ergonomics? To me it's much better with its gesture features and such. Did you mean it as in wrist pain or?