Seems like these structural integrity problems are always inside the Russian section. So if you're on a Russian mission to Mars, yes it would be reasonable to be worried. Otherwise this seems like a non-issue.
This is just not true. There have been leaks due to micrometers in just about every section of the ship at one point or another. A quick search pulls up examples of US modules having issues, especially around interfaces and seals. NASA had a whole investigation between 2018 and 2021 about the recurring issue.
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Unless your spacecraft is built by Boeing.
We had two astronauts stranded in space for the better part of a year just last year!
>Otherwise this seems like a non-issue.
Except you forgot to mention an epic leak in Destiny just three years after it was attached to the ISS: "At its highest rate, the station was leaking about 5 pounds of air per day overboard." [0] Imagine that happening on the 4th year of American Mars mission.
Also, if you on American mission to Mars, it would be reasonable to worry about cooling system dying mid-flight requiring three spacewalks to fix it: "We'd lose cooling capability to half of the electronics on the U.S., European and Japanese part of the space station." [1]