I use a trackpad to avoid virtually all of the issues created by a mouse. The trackpad gestures in macOS are magical.
I have a small Logitech laser mouse with a few auxiliary buttons, horizontal click scroll, and an unlock able wheel for fast scrolling. One button opens up workspace view (four fingers up), side scroll switches between works spaces (four fingers sideways). When my laptop is setup on my desk at home with monitor and keyboard attached this is much more comfortable and efficient than using the track pad. That’s said, MacBook track pads are magic.
What are the issues that a mouse creates?