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> Do you disagree with the assumption that cells are machines?

Yes? Literally no machine ever built by humans is capable of (or even hinting at beginnings of capability for) replication or novel synthesis like cells are, let alone autonomously, it’s quite unconceivable that anyone would take this to be a reasonable assumption in the first place.

Hmmm, well let’s take it one step lower. What do you think of organelles such as ribosomes? Do you disagree with the assumption that those are machines? They seem directly analogous to the jacquard loom or a CNC machine to me.
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replication: https://en.wikipedia.org/wiki/Quine_(computing)

autonomous replication: https://en.wikipedia.org/wiki/Computer_worm

nb that writing your own quine remains in general terms a fun and challenging exercise in many programming languages, but not python.

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The assertion is not that cells are machines built by humans (obviously false), merely that they are machines. Which they pretty clearly are, unless you assume the supernatural.
There is no need to assume the supernatural. They are machines based on what? By definition, a machine is something build by humans, or any intelligent life form (because we extend the definition from our own experience as self defined 'intelligent life forms'). Living organisms and machines do share traits under our current frame of reference in modern science. But that doesn't mean cells are machines. The right framing would be 'cells exhibit behavior and certain internal relations that we can conceptualize them as machines', which is different from 'cells are machines'.
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What exactly is there about cells that's inconceivable to replicate or synthetize? "I cannot conceive it" is a fallacy, an argument from incredulity. Trying to disguise it by draping it in the passive voice does not change that fact.
Nothing. It is just that they are so incredibly complex, that after +100 years of research we still don't know how they work or why. Will there be a time when we finally understand them 100% and could replicate them? Could be. That does not make them machines in any case, and the fallacy of thinking that mind/consciousness can emerge from machines will still be there.