I'm highly agreeable, and I've had to learn not to be. Knowing when to challenge people - "strategic non-agreeableness" - is extremely valuable. I've also made most of my career off being somewhat neurotic - I've described the core of my job as "finding things to panic about before they happen" (I went on Prozac a while back and caused an incident in the first couple weeks during uptake because my anxiety didn't trigger about something during a deploy). As far as extroversion - friends of mine who are genuine extroverts about went crazy during the pandemic, while I and a few other introvert friends got some of our best work ever done during that period. There's a spectrum - you can't be a misanthrope, but being able to take (and stand) quiet time to focus on a problem is absolutely an asset. With regards to conscientiousness, this often manifests in the workplace as an unwillingness to deviate from the plan when circumstances demand it and a preference for adding process as a kind of panacea for any kind of failure or delay, and at risk of offending the more conscientious among us, I have not found that a recipe for success.