When I had my ear surgery about 20 years ago, the doctor explained to me that I would be awake for part of the procedure, but the anesthesia meant that I would have no memory of it.¹ It’s a weird thing to think about whether that lack of memory would obviate the pain or discomfort of the moment.

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1. As it turned out, I was so frightened in the lead-up to the surgery that they had to do general anesthesia on me because I was shaking too much for them to operate so I was unconscious for the whole thing.

From the article:

> The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures.

It's not a great article, and it glosses over the reality that if you hooked this brain up to an EEG it would show unequivocal brain death. CELLS of the brain are alive, but in terms of being able to function in any sort of coordinated way there that ship sailed minutes after the person who donated their organs died. The wave of depolarization that marks brain death isn't something we can reverse, and what's being done here is all about metabolism and structure rather than those much more subtle functions.

IMO the more questionable aspect of this entire operation is the use of "AI" to reach conclusions about how the test molecules are being metabolized, but that's a lot less compelling than implying that some company is somehow preserving life in a disembodied brain.

The word "alive" is doing a lot of work here. A brain is pretty much permanently fried after five to fifteen minutes without oxygen, and these are donor brains, not some emergency brain extraction team, so the timeframe will be much longer than that. There might be 'life' left in there in the technical sense, but there's no 'person' left.

> Live dissection and experimentation on “alive but drugged” human brains is mental.

There’s no such thing as live dissection. It’s vivisection.

Well, we know how to make living brains insensate - that's who we all make it through surgery.

Presumably they're doing something similar - or using some other well-understood mechanism - to ensure that's not the case.

> The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six ethicists on Bexorg’s advisory board. But the company also forestalls any electrical activity with the anesthetic propofol, among other measures. Bexorg obtains brains in partnership with organizations that procure donated organs for transplantation, and Vrselja says once families understand the company’s process and goals, their response is overwhelmingly positive.

It's still an open debate whether the seat of consciousness (or even simpler, perception) is the brain.

see e.g. Wahbeh, H., Radin, D., Cannard, C., & Delorme, A. (2022). What if consciousness is not an emergent property of the brain? Observational and empirical challenges to materialistic models. Frontiers in psychology, 13, 955594. https://doi.org/10.3389/fpsyg.2022.955594

https://en.wikipedia.org/wiki/Hard_problem_of_consciousness

Same for memory, which is "needed" as well for your question to make sense. The more current theories assume memories are stored not only in the brain, but throughout the body.

see e.g. Repetto, C., & Riva, G. (2023). The neuroscience of body memory: Recent findings and conceptual advances. EXCLI journal, 22, 191–206. https://doi.org/10.17179/excli2023-5877

https://en.wikipedia.org/wiki/Body_memory

This, exactly.

Every other part of the human body is understandable but the brain.

Reading the article and imagining its you, sheeeeesh. I really wonder how this passed ethical review. Yes the brain is an organ, and yes there’s probably consent and the body is officially proclaimed dead and this is near the best way to really extrapolate the empirical data prior to alive human trials.

But damn this article is a combination of words I did not want to read today nor imagine.

To add to the discussion in the comments:

There is also the practice of not using anesthesia on infants when undergoing medical surgery.

Anesthesia is hard to do even on adults, harder on children, and very difficult on infants. Not accidentally killing one is quite hard.

So, for a long time we just didn't. I think some countries still don't, but can't remember.

The idea really gets back all the way to philosophy. If you can't remember if you were in pain, did you get hurt? And then you add in the medical problem itself, the duty to do no harm, the difficulties, etc. The conclusion was to just not use pain meds.

Reminds me of a certain scene from Knausgård's Morning Star.

I’ll volunteer to waive my rights here. Feel free to do whatever you wish with my brain once it’s detached from my body :)

Can’t be worse than my organs being harvested for donation.

Brain does not have physical feelings, and with all other feelings cut off and not possible, even with consciousness it won’t be a horror scenario like in MetallicA’s “One”.