It will work fine but it’s not necessarily insane performance. I can run a q4 of gpt-oss-120b on my Epyc Milan box that has similar specs and get something like 30-50 Tok/sec by splitting it across RAM and GPU.

The thing that’s less useful is the 64G VRAM/128G System RAM config, even the large MoE models only need 20B for the router, the rest of the VRAM is essentially wasted (Mixing experts between VRAM and/System RAM has basically no performance benefit).