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Astral was building a private package hosting system for enterprise customers. That was their stated approach to becoming profitable, while continuing to fund their open source work.
Private package hosting sounds like a commodity that would be hard to differentiate.
It's also a crowded and super mature space space between JFrog (Artifactory) and Sonatype (Nexus). They already support private PyPI repositories and are super locked in at pretty much every enterprise-level company out there.
A commodity yes, but could be wrapped in to work very nicely with the latest and greatest in python tooling. Remember, the only 2 ways to make money are by bundling and unbundling. This seems like a pretty easy bundling story.
Yeah you'd think so but somehow JFrog (makers of Artifactory) made half a billion dollars last year. I don't really understand that. Conda also makes an implausible amount of money.
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From my understanding there are a lot of companies that need their own package repositories, for a variety of reasons. I listened to a couple podcasts where Charlie Marsh outlined their plans for pyx, and why they felt their entry into that market would be profitable. My guess is that OpenAI just dangled way more money in their faces than what they were likely to get from pyx.

Having a private package index gives you a central place where all employees can install from, without having to screen what each person is installing. Also, if I remember right, there are some large AI and ML focused packages that benefit from an index that's tuned to your specific hardware and workflows.

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What would be the added value against JFrog or Nexus, for example?
i mean ofc but like you can self-host pypi and the "Docker Hub" model isn't like VC-expected level returns especially as ECR and GHCR and the other repos exist
that was never going to work, let's be honest