I hope those two factors mean that if things go really wrong, then the clean(ish) break with all the non standard complex legacy means an easier future for community packaging efforts.
OpenClaw notably was built around Mario Zechner's pi[0]; uv I believe was highly adapted from Armin Ronacher's rye[1], and uses indygreg's python-build-standalone[2] for distributing Python builds (both of which were eventually transferred to Astral).
[0]: https://github.com/badlogic/pi-mono
In the worst case, Astral will stop developing their tools, someone else will pick them up and will continue polishing them. In the best case, they will just continue as they did until now, and nothing will really change on that front.
Astral is doing good work, but their greatest benefit for the ecosystem so far was showing what's possible and how it's down. Now everyone can take up the quest from here and continue. So any possible harm from here out will be not that deep, at worst we will be missing out on many more cool things they could have built.