LLMs by their nature are not goal orientated (this is fundamental difference of reinforcement learning vs neural networks for example). So a human will have the, let's say, the ultimate goal of creating value with a web application they create ("save me time!"). The LLM has no concept of that. It's trying to complete a spec as best it can with no knowledge of the goal. Even if you tell it the goal it has no concept of the process to achieve or confirm the goal was attained - you have to tell it that.

Not get stuck on an incorrect train of thought, not ignore core instructions in favour of training data like breaking naming conventions across sessions or long contexts, not confidently state "I completely understand the problem and this will definitely work this time" for the 5th time without actually checking. I could go on.

The main thing they cannot do is be held accountable for any decisions, which makes them not trustworthy.