I have made some experiments with P2W, my experimental Python (subset) to WASM compiler. Initial figures are encouraging (5x speedup, on specific programs).
https://github.com/abilian/p2w
NB: some preliminary results:
p2w is 4.03x SLOWER than gcc (geometric mean)
p2w is 5.50x FASTER than cpython (geometric mean)
p2w is 1.24x FASTER than pypy (geometric mean)