If you spend any amount of time on remote machines with unreliable connections, local tmux is insta-reject because tmux inside tmux is very inconvenient. As with GP, it's also why I don't consider terminal emulators without tabs at all.
> because tmux inside tmux is very inconvenient.
Hitting c-b c-b isn't that inconvenient?
Agreed.
I hold Control and double-tap b for managing the remote session, then everything else is the same.
Granted, I'm not a power user, so there may be numbers that get frustrating. I could imagine complex splits getting confusing (I don't use splits at all).
C-b is less ergonomic than C-a that is the default on GNU screen. The first thing in tmux is to remap to C-a. (Triply so if you remap caps lock to ctrl.)
loading story #47212256
I went with C-a for quite a long time, but then I discovered that C-a is a keymap for jumping the cursor to the beginning and f the line, so I remapped tmux prefix to C-Space.