The mention of "quality factor" here just begs the question. The reason we need research on biological effects of high-Z ion exposure is that it has a different mechanism of damage, not captured by that paradigm.
With the current worldwide ageing demographics, it would have the added benefit of providing an awesome feat to inspire seniors across the world to not go gentle into that good night, showing old age should burn and rave at close of day.
A hypothetical 500 day mars mission is ~1 Sv optimistically which is something like 5% fatal cancer risk. A 3 year mission you’re well above that even before considering solar storms etc.
I think many would sign up for a mars mission especially as treatment improves, but there’s only so much wiggle room here.