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I'm a big fan of fundamental knowledge, but I disagree somewhat with your statement. The thing that startups care most about is a product market fit. And finding that fit requires a lot of iteration and throw-away code. Once the dust settles and you have an initial user base, you can start looking into optimizations.
> Once the dust settles and you have an initial user base, you can start looking into optimizations.

But people never do. Instead they just scale up, get more funding, rinse and repeat. It isn't until the bill gets silly that anyone bothers to consider it, and they usually then discover that no one knows how to optimize things other than code (maybe – I've worked with many devs who have no idea how to profile their code, which is horrifying).

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