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The overwhelming majority of listings on the site were for personal use quantities.
The overwhelming majority of drug sales are for personal use. That doesn't mean that large sales weren't made, or that those weren't in fact a significant portion of the site's revenue.
>it's not like there's a chain of provenance, and there's no particular guarantee that whatever grade of pure drugs was sold on Silk Road is the same purity that ended up in peoples' bodies.

The fact that the majority of listings on the site were for personal use quantities suggests that the majority of sales were to end users rather than traffickers.

It's hard to dispute that this saved lives and I would speculate that it saved many lives.

>That doesn't mean that large sales weren't made, or that those weren't in fact a significant portion of the site's revenue.

Nobody made any claim that large sales weren't made, of course they were.

> It's hard to dispute that this saved lives and I would speculate that it saved many lives.

See below; the observation is that the people who were buying individual quantities of drugs from SR were not at serious risk of harm in the first place, relative to typical at-risk populations. Anecdotally, the people I know who bought drugs from SR during its heydey were very much test-everything-twice types.

By contrast, the large sales that SR facilitated almost certainly ended up in street drug markets, where harm reduction would have made a difference. But those people didn't benefit from SR's community standards, insofar as they existed: they got whatever adulterated product made it to them.

This is the basic error in saying "most sales were small": the big sales are what matter, socially speaking.