Newton, Leibniz; Einstein, Lorenz and Riemann; Shannon, Kolmogorov; Crick, Franklin.
When the context is, to quote the parent comment:
> I look at some names and think, "who?" or "I've heard the name, but know nothing about him." I mean, of course you can still read about them, but that even a US President can be largely forgotten as a household name within 250 years is really a stunning thing to think about
I suspect only Newton and Einstein are even household names. I'd be very surprised if the average person has heard of even one of Lorenz, Riemann, Shannon, Kolmogorov, or Crick, even today, and my guess is that Franklin would probably be assumed to be an associate of either Roosevelt or Benjamin, given the widely claimed but inconsistently cited survey that 12% of Americans think Joan of Arc was Noah's wife.
And Crick's other famous research associate was Watson; I wonder how many times people got him mixed up with the fictional character, or briefly for the IBM computer.