Offhand the only drug-like thing I remember from that series is the nutrition bars that had 0 calories that most of the school got addicted to. Or maybe the cheerleader that got bee pheromones and started controlling the rest of the students.

Aside - I just learned a month ago that there's an official followup miniseries that brought back several of the original actors, titled "Echoes", with hopefully more coming since it's called Season 1. Came out over 2022-2023: https://www.youtube.com/playlist?list=PLHGrvCp5nsDJ1qSoKZEmm... (the trailers are at the bottom of the playlist)