The complexity for you comes from trying to reuse their (battle tested) implementation when (as I wrote above) the primitives they depend upon were not meant to make porting to a browser sandbox easy.

And the problems there are the specific concurrency model they depend upon: communicate by sharing memory.

Then, you're either working at the wrong abstraction level (and it shows), or you're patching and gutting SQLite.

SQLite is meant to work with files, file locks, shared memory, fsync and mmap.

It also doesn't work out great if you try to persist to an object store, to a KV store, or…

I'm repeating myself, but yeah. You can make it work. Others have made it work. But it's still a lot of work, and you're throwing away a lot of what makes SQLite… SQLite.