Some things are a bit awkward, but what specifically can't you really do in a Python REPL? You can dynamically overwrite functions in an imported module, you can re-import modules with importlib, etc. I ask because my Lisp experience is limited.
Lisp REPL keeps the state of the program because it is a live image. With Python REPL you need to rerun the program to set the variables to their values.
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